why psoriasis should be shed light?

Psoriasis is a chronic, recurrent, non-contagious, painful, immune-mediated skin inflammatory disease with a prevalence in countries ranging between 0. 09%–11. 43% that has a major negative impact on a patient's quality of life by applying psychological and physical stress [1]. It is a complex disease and is mainly characterized by hyperproliferation and abnormal differentiation of keratinocytes in the epidermis. The resulting production of cytokines, chemokines, and growth factors cause excessive proliferation, aberrant differentiation of keratinocytes and excessive inflammatory cell infiltration into the dermis and epidermis [2]. Variations in specific genes cause changes in the regulatory mechanisms of specific genes involved in mechanisms in the immune system and the other skin systems in keratinocytes. Effects of these variants on gene regulatory mechanisms in the keratinocytes have to be shed light to better understand the pathogenesis of psoriasis. On the other hand, although the relationship between the change in the microbial community in the skin and psoriasis has been studied extensively in recent years, the relationship of the skin microbiota to the host skin mechanisms is still unclear. Ultimately, despite immense technological advances in medicine, the mechanisms of psoriasis still remain unclear and most importantly, current treatments cause serious side effects while reducing symptoms. Therefore, drug development, targeted therapies, and biomarker identification for psoriasis are important.